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Dr. Grzegorz Sawicki

Research Interests of Dr. G. Sawicki

 

 

GS

Grzegorz (Greg) Sawicki, Ph.D.

Associate Professor
Department of Pharmacology
College of Medicine
University of Saskatchewan


Tel:   306-966-6997
Fax:  306-966-6220
E-mail:  greg.sawicki@usask.ca

 

 


 

 

Academic Credentials

B.Sc., Department of Biochemistry, Faculty of Natural Science, University of Wroclaw, Poland
M.Sc., Department of Biochemistry, Faculty of Natural Science, University of Wroclaw, Poland
Ph.D., Medical University, Wroclaw, Poland

 

Research Interests

  • Molecular mechanisms of heart injury triggered by oxidative stress and its protection from contractile dysfunction. 
  • Use of the pharmaco-proteomics approach in pathological and physiological heart studies. 
  • Novel intracellular function of matrix metalloproteinase-2 in heart injury.
  • Posttranslational modifications of contractile proteins triggered by oxidative stress and their role the injury.


Publications

M.  Emara, P-Y.   Cheung, K.  Grabowski , G.   Sawicki, M.  Wozniak. Serum Levels of Matrix Metalloproteinase -2 and -9 and Conventional Tumor Markers (CEA and CA 19-9) in Patients with Colorectal and Gastric Cancers. Clinical Chemistry and Laboratory Medicine. 47::993-1000, 2009.

A. Doroszko, D. Polewicz, J. Sawicka, J.S. Richardson, P-Y. Cheung, G. Sawicki. Cardiac dysfunction in an animal model of neonatal asphyxia is associated with increased degradation of MLC1 by MMP-2. Basic Res Cardiol. In press, 2009.

S. Robichaud, M. Lalu, T. Udenberg, R. Schulz, G. Sawicki. Proteomics Analysis of Changes in Myocardial Proteins During Endotoxemia. Journal of Proteomics. 72:648-655, 2009

S. Viappiani, A.C. Nicolescu, A. Holt, G. Sawicki, B.D. Crawford, H. León, T. Van Mulligan, Richard SchulzActivation and modulation of 72 kDa matrix metalloproteinase-2 by peroxynitrite and glutathione. Biochemical Pharmacology, 77:826-834, 2009

J. Fert-Bober, G. Sawicki, G. D. Lopaschuk, P-Y Cheung. Proteomic Analysis of Cardiac Metabolic Enzymes in Asphyxiated Newborn Piglets. Mol. Cell. Biochem. 318:13-21, 2008.

J. Fert-Bober, H. Leon, J. Sawicka, R. S. Basran, R.M. Devon, R. Schulz, G. Sawicki. Inhibiting matrix metalloproteinase-2 reduces protein release into coronary effluent from isolated rat hearts during ischemia-reperfusion. Basic Res Cardiol. 103:431-443, 2008.

J. Fert-Bober, R.S. Basran, J. Sawicka, G. Sawicki. Effect of duration of ischemia on myocardial proteome in ischemia/reperfusion injury. Proteomics, 8:2543-2555, 2008.

A.A. Olkowski, C. Wojnarowicz, M. Chirino-Trejo, B. Laarveld, G.Sawicki. Sub-clinical necrotic enteritis in broiler chicken: Novel ethiological consideration based on ultra-structural and molecular changes in the intestinal tissue. Res. Vet. Sci, 85:543-553, 2008.

H. León, I. Baczkó, G. Sawicki, P.E. Light, R. Schulz. Inhibition of matrix metalloproteinases prevents peroxynitrite-induced contractile dysfunction in the isolated cardiac myocyte. Brit. J. Pharmacol. 153:676-683, 2008.

M-L. Baudet, Z. Hassanali, G. Sawicki, E.O. List, J. J. Kopchick, S. Harvey. Growth hormone (GH) actions in the developing neural retina: A proteomic analysis. Proteomics, 8, 389-401, 2008.

M.M. Sung, C.G. Schulz, W. Wang, G. Sawicki, R. Schulz. Matrix metalloproteinase-2 degrades the cytoskeletal protein alpha-actinin in peroxynitrite mediated myocardial injury. J. Mol. Cell. Cardiol. 43:429-36, 2007.

G. Sawicki and B.I. Jugdutt. Valsartan reverses post-translational modifications of the delta-subunit of ATP synthase during in vivo canine reperfused myocardial infarction. Proteomics, 7:2100-2110. 2007.

M. Sariahmetoglu, B.D. Crawford, H. Leon, J. Sawicka, L. Li, B.J. Ballermann, C. Holmes, L.G. Berthiaume, A. Holt, G. Sawicki, R. Schulz. Regulation of matrix metalloproteinase-2 activity by phosphorylation. FASEB J  21:2486-95, 2007

J.A. Beyea, G. Sawicki, D.M. Olson, J.J. Kopchick, S. Harvey. Growth hormone (GH)- receptor knockout mice reveal actions of GH in lung development. Proteomics, 6: 341-348, 2006.

G. Sawicki, H. Leon, J. Sawicka, M. Sariahmetoglu, C.J. Schulze, P.G. Scott D. Szczesna-Cordary, R. Schulz. Degradation of Myosin Light Chain In Isolated Rat Hearts Subjected To Ischemia–Reperfusion Injury: A New Intracellular Target for Matrix Metalloproteinase-2. Circulation, 112: 544-552, 2005.

G. Sawicki, Y. Marcoux, K. Sarkhosh E.E. Traget, A. Gahary. Interaction of Keratinocyte and Fibroblast Modulates the Expression of Matrix Metalloproteinases-2 and -9 and Their Inhibitors. Mol. Cell. Biochem. 269: 209-216, 2005.

G. Sawicki, V. Menon, B. I. Jugdutt. Improved balance between TIMP-3 and MMP-9 after regional myocardial ischemia-reperfusion during AT1 receptor blockade.  J Cardiac Failure, 10: 42-449, 2004.

J.A. Kwan, C.J. Schulze, W. Wang, H. Leon, M. Sariahmetoglu, M. Sung, J. Sawicka, D. E. Sims, G. Sawicki, R. Schulz Matrix metalloproteinase-2 (MMP-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP-ribose) polymerase (PARP) in vitro. FASEB J. 18: 690-692, 2004.

G. Sawicki and B.I. Jugdutt. Detection of Regional Changes in Protein Levels in the in vivo Canine Model of Acute Heart Failure Following Ischemia-Reperfusion Injury - Functional Proteomics Studies. Proteomics, 4: 2195-2202, 2004.

 

Professional Affiliations

Member, Cardiovascular Research Group
    http://www.usask.ca/healthsci/cardiovascular

Member, Pharmacological Society of Canada
    http://www.physpharm.med.uwo.ca/psc

Member, International Proteolysis Society
    http://www.protease.org

Member, Swiss Proteomics Society
    http://www.swissproteomicsociety.org