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Dr. Lixin Liu
Research Interests of Dr. Lixin Liu
Lixin Liu, Ph.D.
Assistant Professor
Department of Pharmacology
College of Medicine
University of Saskatchewan
Tel: 306-966-6300
Fax: 306-966-6220
E-mail: lixin.liu@usask.ca
Academic Credentials
B.M.Sc.(MD), Faculty of Medicine, Soochow University School of Medicine, China
M.M.Sc., Soochow University School of Medicine, China
Ph.D., Uppsala University, Sweden
Research Interests
- The role of intracellular signaling molecules in leukocyte recruitment and transendothelial migration.
The recruitment of leukocytes from the flowing bloodstream into inflamed tissues is of key importance in inflammation. This recruitment involves complex interactions between leukocytes and vascular endothelial cells, characterized as firstly the tethering and rolling of leukocytes along the endothelium followed by leukocyte activation and firm adhesion to the endothelium, the transmigration of leukocytes across the endothelium (diapedesis), and finally the chemotactic migration of emigrated leukocytes toward the site of infection or injury (chemotaxis). These dynamic processes involve sophisticated cellular and molecular interactions and multiple signaling events among cell adhesion molecules, chemotactic signals, and intracellular signaling pathways. The cellular and molecular mechanisms and the role of intracellular signaling molecules in both leukocytes and endothelial cells involved in the leukocyte recruitment are our research interests in the lab.
Publications
L. Liu, K.D. Puri, J.M. Penninger, and P. Kubes, 2007. Leukocyte PI3K-gamma and PI3K-delta have temporally distinct roles for leukocyte recruitment in vivo. Blood (in press). Blood First Edition prepublished online May 8, 2007; DOI 10.1182/blood-2006-11-060103.
L. Liu, and P. Kubes. Chemokines in leukocyte transendothelial migration [Book chapter]. Chemokine Biology: Basic Research and Clinical Application. 2006; pp109−pp122.
M. Phillipson, B. Heit, P. Colarusso, L. Liu, C.M. Ballantyne and P. Kubes, 2006. Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade. J Exp Med. 27;203(12):2569-75.
L. Liu, D.C. Cara, J. Jaur, E. Raharjo, S.C. Mullaly, J. Jongstra-Bilen, J. Jongstra, and P. Kubes, 2005. LSP1 is an endothelial gate keeper of leukocyte transendothelial migration. J. Exp. Med. 201(3): 409-418. (J. Exp. Med. news report: LSP1: Gatekeeper of the endothelium. J. Exp. Med. 201(3): 319.)
A.I. Khan, S.M. Kerfoot, B. Heit, L. Liu, G. Andonegui, B. Ruffell, P. Johnson, and P. Kubes, 2004. Role of CD44 and hyaluronan in neutrophil recruitment. J. Immunol. 173: 7594-7601.
R.C.O. Zanardo, C.S. Bonder, J.M. Hwang, G. Andonegui, L. Liu, D. Vestweber, L. Zbytnuik and P. Kubes, 2004. A Down Regulatable E-selectin Ligand is Functionally Important for PSGL-1-Independent Leukocyte−Endothelial Cell Interactions. Blood 104(12): 3766-3773.
L. Liu, and P. Kubes, 2003. Molecular mechanisms of leukocyte recruitment: organ-specific mechanisms of action. Thromb. Haemost. 89(2): 213-220.
L. Liu, L. Håkansson, P. Ridefelt, R.C. Garcia, and P. Venge, 2003. Priming of eosinophil migration across lung epithelial cell monolayers and upregulation of CD11b/CD18 are elicited by extracellular Ca2+. Am. J. Respir. Cell Mol. Biol. 28: 713-721.
Professional Affiliations
Member, Cardiovascular Research Group
http://www.usask.ca/cardiovascular
Member, Canadian Hypertension Society
